This is a study to evaluate the efficacy and safety of AZD0780 in adults with clinical ASCVD or who are at risk for a first ASCVD event and who have elevated LDL-C. AZD0780 is a small molecule that reduces the amount of LDL-C in the blood.

This is a Phase III study to evaluate the effect of balcinrenone/dapagliflozin in patients with heart failure and impaired kidney function.

The Preventable study is investigating the role of statins in older adults, to determine the risk/benefit for prevention of cardiovascular disease or dementia at baseline, and to see if statins may reduce death, dementia, and persistent disability, mild cognitive impairment and dementia, and cardiovascular events.