S1918: New Approaches for Lymphoma in Older Adults with Aggressive Variants
Official Title: S1918, A Phase II/III randomized study of R-miniCHOP with or without CC-486 (oral azacitidine) in patients age 75 years or older with newly diagnosed diffuse large B cell lymphoma, Grade IIIb follicular lymphoma, transformed lymphoma, and high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements (NCT 04799275)
Sponsor: SWOG, NCTN, NIH, NCI
Principal Investigator: Lindsey Fitzgerald, MD
Conditions: Diffuse Large B Cell Lymphoma
Study Description: This phase II/III trial compares the side effects and activity of oral azacitidine in combination with the standard drug therapy (reduced dose rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone [R-miniCHOP]) versus R-miniCHOP alone in treating patients 75 years or older with newly diagnosed diffuse large B cell lymphoma. R-miniCHOP includes a monoclonal antibody (a type of protein), called rituximab, which attaches to the lymphoma cells and may help the immune system kill these cells. R-miniCHOP also includes prednisone which is an anti-inflammatory medication and a combination of 3 chemotherapy drugs, cyclophosphamide, doxorubicin, and vincristine. These 3 chemotherapy drugs, as well as oral azacitidine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Combining oral azacitidine with R-miniCHOP may shrink the cancer or extend the time without disease symptoms coming back or extend patient's survival when compared to R-miniCHOP alone.
Learn More:
https://clinicaltrials.gov/study/NCT04799275?tab=history&a=247